Antioxidants inhibit mercuric chloride-induced early vasculitis

Antioxidants inhibit mercuric chloride-induced early vasculitis.

In the Brown Norway (BN) rat, mercuric chloride (HgCl(2)) induces a T(h)2-dominated autoimmune syndrome which includes an early phase of mast cell-dependent vasculitis. We have shown in vitro that oxidative stress up-regulates IL-4 in mast cells and predisposes to degranulation. The aim of this study was to determine whether administration of antioxidants inhibits HgCl(2)-induced early vasculit...

Antioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity

The effects of Arabic gum (AG) against nephrotoxicity of mercury (Hg), an oxidative-stress inducing substance, in rats were investigated. A single dose of mercuric chloride (5 mg/kg intraperitoneal injection) induced renal toxicity, manifested biochemically by a significant increase in serum creatinine, blood urea nitrogen, thiobarbituric acid reactive substances, and total nitrate/nitrite prod...

Eye injury with mercuric chloride.

With the advent of modern ophthalmic treatment the use of mercury preparations in ophthalmology has almost been relegated to past history, but mercurous chloride (calomel) is still occasionally used as an insufflation into the eyes, especially in such conditions as phlyctenular keratoconjunctivitis. Recently we saw a case wherein mercuric chloride (HgCl2) was mistaken for calomel and dusted int...

Mercuric Chloride-Induced Vasculitis in the Brown Norway Rat: a p T Cell-Dependent and -Independent Phases

Effect of Sodium Selenide on Renal Toxicity Induced By Mercuric Chloride in Rat

Background and Aims: Mercury, with its oxidative activity, causes damage to the antioxidant enzymes thus resulting in physiological disorders. Sodium selenide is an antioxidant that protects antioxidant enzymes. The aim of this study was to investigate the protective effect of sodium selenide on renal toxicity induced by mercuric chloride in rats. Materials and Methods: Animals were divided in...